Sunday 27 January 2019

Venomous: How Earth's Deadliest Creatures Mastered Biochemistry by Christine Wilcox







You may have heard that everything is a toxin in the right dose, but that's not quite true.  A large enough dose can make something toxic, but if it takes a lot to kill you, then a substance isn't a toxin.




Platypuses are really awfully, terribly venomous.  From what I've heard, being stung by a platypus is a life-changing experience, as any deeply traumatic event shapes who you are.  Their venom causes excruciating pain for several hours, even days.




King cobras can deliver up to 7 milliliters of venom with every bite -- enough to kill twenty people!




There is a long history of using venomous animals for violence -- so much that in several ancient cultures, specific punishments are detailed for those who commit such crimes.




The Vish Kanya -- legendary young women assassins in India during the Mauryan Empire (321-185 B.C.) who were said to be bitten by snakes from birth until their very blood and saliva were so toxic with venom that they could kill with a kiss.





In Egypt, death by snakebite was thought to give a person spiritual immortality. In Alexandria, snakebite was generally considered a humane method of execution.




Bees and their relatives kill more people every year in the United States than snakes, scorpions, and spiders combined -- ten times as many, in fact.





In the Arctic, mosquito populations can be so dense that caribou herds will alter their migration course just to avoid them.  The bloodsuckers have been known to drain 300 milliliters of blood -- almost a soda can's worth -- from every single caribou in a herd daily.




The Komodo dragon (Varanus komodoensis) is the largest living lizard in the world.  The biggest one on record measured more than ten feet long and weighed more than 360 pounds.  They're intimidating beasts known to feed on anything they want, from pigs to water buffalo (which can stand more than six feet at the shoulder and weigh more than one thousand pounds).



Out of the eight thousand venomous snakebites that occur annually in the United States --most of which are attributed to rattlesnakes -- fewer than a dozen are fatal.




Necrosis is defined as the death of living tissue, but the clinical definition fails to encapsulate just how disgusting and horrible tissue death is.  Necrotic venoms leave large areas of skin and even entire limbs rotten and gangrenous, oozing blood and pus and stinking of decay. Healthy, pink tissue becomes black in death, swelling from fluid from liquefied flesh, until it falls from the bone in putrid, zombified chunks.




The worst necrotic venoms don't just tear through cells on their own: they enlist our own immune system to continue the death and destruction.




Our immune cells are trained to fight to the death -- which, in the case of bacterial or viral infection, is a great thing.  But in the case of snake venom, there's no one to kill.




In America, a sly smile and a few Benjamins might buy you an eight ball of cocaine, but in Delhi, a similar amount could get you a taste of cobra venom.




Traditional Indian medicine, referred to as Ayurveda, frequently employed snake venoms as therapeutics, delivering them on the tip of a needle (a technique called suchikavoron) or after a detoxification process (shodhono).




There are several documented cases where venoms appear to have treated what doctors failed to.  One of the most incredible stories I have ever heard is that of Ellie Lobel, a woman who was dying of Lyme disease until she was viciously attacked by a swarm of Africanized bees.




Melittin -- the most abundant component of bee venoms -- is a potent antibiotic.  In high doses, it tears holes in bacterial cells, killing them.